Published on March 11th, 20130
New hybrid tooth implant. Scientists can grow teeth from mouse cells
Researchers have succeeded in creating “hybrid tooth” combining human gum cells and stem cells from mouse teeth. Scientists hope that the teeth grown in mice will eliminate prosthetic denture and replacing them with new grown directly in the mouth.
In the future, people will be able to replace missing and decayed teeth with new ones grown using cells taken from their own mouths, according to scientists.
The mixture of cells from mice and humans kidney was transplanted into an adult mice and structures developed: teeth with enamel and roots, a study published in the Journal of Dental Research.
Scientists have used two types of cells to conceive these teeth. Epithelial cells were extracted from tissue derived from the gum, and mesenchymal stem cells were extracted from mouse embryos.
Mesenchymal cells can develop in many types of tissue, including cartilage, bone or fat.
Professor Paul Sharpe, who led the research at the Institute of Dentistry at King’s College London, says that “epithelial cells derived from adult human tissue from the gum can respond to signals from mesenchymal cells indicating the development of a tooth, helping to build dental crown and roots”. The researcher added that “these epithelial cells are easily collected and they are considered a necessity for human “hybrid teeth“. The next challenge is to find a method by which mesenchymal cells cultured in an adult human being to stimulate tooth growth, because at this time we do this only with embryonic stem cells”.
“We need to identify sources of adult epithelial and mesenchymal cells that can be obtained in sufficient quantities to make the “hybrid teeth” design a viable alternative to dental implants”, concluded Sharpe.
Source: The Guardian